SAC® Research Library
Published studies, clinical data and reference material on Sigma Anti-Bonding Calcium, organized by type of evidence so you can see exactly what each source shows.
Each source carries a label for the kind of evidence it is. They answer different questions, so they are listed separately.
Human · Peer-reviewedResults in people, published in a peer-reviewed journal.
Human · Internal dataOur own de-identified records, summarized here. Raw data on request.
PreclinicalAnimal and cell studies that test how SAC® acts on bone.
Mechanism · ReferenceChemistry and the literature behind calcium signaling.
Disclosure Some of the research listed here involves the Calcium & Bone Health Institute (CBHI), an organization associated with Marah Natural. Please read these sources with that in mind.
01
What happened to bone density in adults taking SAC®.
Yoon D, Lee A, … Lee PK, Park JY · J Family Med Prim Care Open Acc 9: 290
In plain language: 82 adults took SAC® for about eight months. Bone density at the wrist rose in every group (normal, low and very low bone density at the start), for men and women of all ages.
Study design: retrospective, single-arm, quantitative ultrasound at the distal radius. No comparison group.
Marah Natural · October 2026 · 10 pages, plus a 66-page de-identified data appendix
In plain language: We re-analyzed our own clinic records from 2014 to 2018, the same clinic setting as the published study. Of 2,904 people screened, 57 SAC® users had a repeat scan. Every one of them had a higher T-score at follow-up, about four to five months later.
Study design: uncontrolled, retrospective, peripheral ultrasound. Shared to inform the design of a controlled study.
02
How SAC® acts on bone cells and bone structure.
Oh Y, Yoo BC, … Cho JY · Calcified Tissue International (2026) 117: 141 · Sungkyunkwan University
In plain language: In a model of bone loss after menopause, SAC® helped preserve bone density and the inner structure of bone over 13 weeks. In cell tests it slowed the formation of osteoclasts, the cells that break bone down.
03
The chemistry of SAC® and the science of calcium signaling.
Calcium & Bone Health Institute · 2nd edition, 2025 · 392 pages · ISBN 978-1-7753211-2-5
The full scientific background: ionization, solubility, absorption routes and calcium's role as a signal in bone, nerve and muscle.
Explore the proposed science behind SAC®, from its bonding structure and interaction with water to calcium ion availability.
Explore SAC® Technology →04
A contract-lab study report and an unpublished manuscript. Neither is peer-reviewed yet, and both are animal data.
Charles River Discovery Services · Colo205-e396 · January 2025 · Not peer-reviewed
In mice carrying human colorectal tumor cells, SAC-SG (150 mg/kg, twice daily by mouth for 21 days) was followed by a smaller median tumor volume than vehicle: 498 vs. 726 mm³, a 31.4% tumor growth inhibition. Treated animals lost more weight early on before partly recovering. Animal data only, with no statistical analysis shown in the report.
Read the Study Report →
Mehdi SH, Lee D, Lee A, et al. · For review only
A mouse study of whether SAC® influences bone formation, and how that may affect the bone marrow environment in which myeloma cells grow. Findings are preliminary and may change before publication. They do not show prevention or treatment of any disease in people.
Read the Early Preview →Questions about the research?
If you would like the raw data, a citation, or more detail on any source listed here, send us a note and we will get back to you.
Contact Us →help@MarahNatural.com
MarahDeo Holdings Corp. · Unit 110, 16 Fawcett Road, Coquitlam, BC V3K 6X9, Canada · help@MarahNatural.com
Research summaries are provided for professional and educational purposes. Preclinical findings do not establish effects in humans, and individual results vary. *These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
