New breakthrough evidence shows improved bone mineral density with advanced calcium absorption via SAC®
A new peer-reviewed clinical article has found that Marah Natural’s SAC® (Sigma Anti-Bonding Calcium Carbonate) Formulation Technology may significantly improve bone mineral density and quality in older adults. This new clinical article was published in the Gavin Journal of Food & Nutrition on October 6th, 2025. This research was built on years of preclinical work, confirming in real people what laboratory data has suggested for years: calcium only protects bone when it is absorbed effectively, not merely consumed.
The study builds on years of preclinical research, confirming in real people what lab results have long suggested: effective calcium absorption is key to maintaining bone strength and resilience as we age.
While modest in scale, the findings offer encouraging, real-world evidence that advanced calcium delivery through SAC® formula can support measurable improvements in bone health.
Bone mineral density declines silently with age, often without symptoms until it is advanced. Loss of bone mass over time leads to reduced confidence, mobility, and independence. Marah Natural’s SAC® formula represents a next-generation approach to calcium supplementation, grounded in science, verified through peer review, and designed to help people maintain stronger, more resilient bones as they age.
T-score changes by gender and clinical groups
BMD changes by gender and clinical groups
T score change after SAC® treatment
Key Findings: Meaningful Gains Across All Groups
After approximately eight months of daily use, 82 participants saw significant improvements across all bone health indicators:
- Bone Mineral Density (BMD) increased from 0.95 → 1.10 g/cm²
- T-Scores improved from –2.0 → –0.85
- Bone Quality (SOS) rose from 3,946 → 4,079 m/s
Even more encouraging:
- 65% of participants with osteopenia improved to normal bone mineral density
- 64% of participants with osteoporosis improved to osteopenia
- 12% of those with osteoporosis achieved normal bone mineral density
Results were consistent across age groups and genders, with postmenopausal women showing the highest percentage of improvement (≈15%).
About the Study: Real People, Real Results
Published in the Gavin Journal of Food & Nutrition Science, the study evaluated the effects of SAC® calcium supplementation on bone mineral density and bone quality in 82 older Asian adults. Participants were grouped by bone health status: normal, osteopenia, or osteoporosis, and took SAC® formula daily for around eight months.
Researchers measured:
- Bone Mineral Density (BMD)
- T-scores (a comparison to peak bone mass)
- Bone quality via ultrasound “speed of sound” (SOS), a non-invasive indicator of bone strength.
Distribution of clinical group before and
after treatment based on T-score
How the Study Was Conducted
The clinical study was carried out at a medical clinic in Vancouver, Canada, following approval by an independent ethics review board (Protocol No. MCC23681).
- Who participated: 82 older adults of Asian descent, all showing signs of low bone mineral density or early-stage osteoporosis. Asian populations have higher susceptibility to osteoporosis.
- Bone health categories: Normal (18), Osteopenia (31), Osteoporosis (33)
- Average age of participants: 54 – 64 years
- Where the study took place: This retrospective study was conducted at a medical clinic in Vancouver, Canada
- Procedure: Each person consumed 7.6 mg of SAC® calcium carbonate daily, diluted in 500 mL of water per 70 kg body weight, twice a day on an empty stomach.
- Duration of study: The intervention lasted for approximately eight months (average ≈ 260 days).
- What was measured: Researchers assessed bone mineral density (BMD) and bone quality before and after supplementation, using validated ultrasound-based measurements.
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- Bone quality was measured using a BeamMed MiniOmni™ portable ultrasound, which is a radiation-free and non-invasive method suitable for population studies.
- Measurements were taken from the distal radius (forearm), a clinically relevant site for assessing peripheral bone mineral density.
- What was found: Results showed a statistically significant increase in both bone mineral density and bone quality scores, suggesting improved bone strength and structure.
These results suggest SAC® may not only slow bone loss but actively support natural bone rebuilding and mineralization.
Distribution of clinical group before and
after treatment based on T-score
Why SAC® Formula Works Differently
Conventional calcium carbonate requires digestion and relies heavily on vitamin D and peptides for absorption. In contrast, SAC® functions at the molecular level to deliver ionic calcium: the only form the body can use directly. This means it can enter the bloodstream without relying heavily on vitamin D or peptides for absorption, which is often an issue in older adults.
By supporting the body’s natural process of bone remodeling, SAC® may help maintain or restore density where other forms of calcium fall short.
SAC® enters the bloodstream via passive diffusion through the gastric and duodenal walls, independent of digestion, vitamin D, or ATP.
The Takeaway for Your Bone Health
For those concerned about bone thinning, fragility, or early signs of osteoporosis, the message is clear: Absorption matters. The form of calcium you take, and whether your body can actually use it, can change long-term outcomes.
Marah Natural’s SAC® Formula represents a next-generation approach to calcium supplementation, grounded in science, verified through peer review, and designed to help you move with strength and confidence at any age.
Citation
Yoon D, Lee A, Yusuf I, Putranto T, Setiawan L, et al. (2025) A Potent Calcium Dietary Consumption Improves Bone Mineral Density in Asian Older Adults. J Family Med Prim Care Open Acc 9: 290. https://doi.org/10.29011/2688-7460.100290
Read the full study:Responsible Science: Recognizing the Study’s Limitations
While the results are promising, Marah Natural and our research collaborators emphasize the importance of scientific transparency.
1. Study Type
This was an open-label clinical study, not a randomized controlled trial (RCT).
An RCT in diagnosed osteoporosis patients would require withholding calcium from a control group, a design most ethics boards will not approve.
Instead, researchers chose a real-world observational design, ensuring all participants received potentially beneficial treatment while still allowing meaningful before-and-after analysis.
2. Measurement Method
The study used ultrasound-based bone assessments rather than DXA (the clinical gold standard).
While DXA provides more precise readings, ultrasound is radiation-free, accessible, and cost-effective — ideal for community and population-level studies. Previous literature supports ultrasound as a valid indicator of bone quality and fracture risk.
3. Study Size & Duration
With 82 participants over ~8 months, this was a moderate-scale clinical investigation, suitable for a first human study.
Future research will expand sample size, include DXA imaging, and explore long-term outcomes such as fracture reduction.